curative effects of cassia fistula fruit extract on bromobenzene-induced hepatotoxicity and nephrotoxicity in mice

background & objectives: the present investigation was designed to evaluate the post-treatment properties of the hydroalcoholic fruit extract of cassia fistula (golden shower tree) in male albino mice. materials & methods: biomarkers and histological liver and kidney alterations, aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), γ-glutamyl transferase (γ-gt), bilirubin, blood urea nitrogen (bun) and creatinine were evaluated. animals were divided into six groups: negative control (received daily normal saline), positive control (received daily bromobenzene (bb) 460 mg/kg) and groups three to six received 200, 400, 600 or 800 mg/kg hydroalcoholic c. fistula extract as oral gavages for 10 days two hours following an administration of bb 460 mg/kg. results: administration of 460 mg/kg dose of bb produced a significant increase in the activities of biomarker enzymes [except for direct bilirubin (dbil)], when compared to negative control (p